Corneocyte desquamation

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Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

G E Pierard1, V Goffin, T Hermanns-Le

  • 1Department of Dermatopathology, CHU Sart Tilman, B-4000 Liege, Belgium.

International Journal of Molecular Medicine
|July 13, 2000
PubMed

Insights

Corneocyte desquamation, the skin

Area of Science:

  • Dermatology and Skin Biology
  • Cell Biology
  • Biochemistry

Background:

  • Corneocyte desquamation is a crucial skin process for shedding dead cells.
  • Altered desquamation leads to skin conditions like xerosis and ichthyosis.
  • Understanding desquamation is key to managing various dermatological disorders.

Purpose of the Study:

  • To review the biological and molecular mechanisms of normal and altered corneocyte desquamation.
  • To explore the interplay between epidermal homeostasis and desquamation.
  • To identify factors influencing the desquamation process.

Main Methods:

  • Literature review of biological and molecular aspects of corneocyte desquamation.
  • Analysis of the relationship between epidermal cell dynamics and desquamation.
  • Examination of factors affecting stratum corneum barrier function and enzymatic corneodesmolysis.

Main Results:

  • Corneocyte desquamation is a tightly regulated process involving epidermal cell production, maturation, and loss.
  • Corneocyte hydration, barrier function, and enzymatic corneodesmolysis are dynamically interrelated.
  • Physiological and environmental factors significantly influence desquamation timing and efficacy.

Conclusions:

  • Normal corneocyte desquamation ensures inconspicuous shedding of single cells.
  • Dysregulation of desquamation contributes to pathological skin conditions.
  • Further research into the complex factors governing desquamation can inform therapeutic strategies for skin disorders.

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