Connections among parent and child atopic illnesses

This study investigated parent-child connections for the atopic illnesses of asthma, eczema, food allergies, and hay fever, in a sample of 325 families. Parents reported whether they or their children currently had each condition and rated the frequency and intensity of its episodes; these ratings were combined to estimate illness severity. The data revealed five main findings. First, chi-square parent-child concordance analyses indicated that children of parents with any of the atopic illnesses studied were significantly more likely to develop that same disease than were children of parents without the illness. Second, children were progressively more likely to have at least one atopic illness when the number of their parents who were atopic increased from zero to two. Third, the number of atopic illnesses in the children was associated with the number of atopic illnesses in the parents. These three findings augment the evidence for genetic factors in the development of atopic illnesses and suggest that the atopies of each parent may contribute to an aggregate, generalized risk for their children. Fourth, maternal atopy was more strongly related to the children's asthma and hay fever than paternal atopy. Fifth, the severity of the children's specific atopic illnesses was not affected by the number of their parents who had the same condition and was not strongly related to the severity of their parents' condition.