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Kinetic studies on Ce(IV)-induced hydrolysis of single-stranded and double-stranded oligonucleotides
T Igawa1, J Sumaoka, M Komiyama
1Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Japan.
Nucleosides, Nucleotides & Nucleic Acids
|July 14, 2000
Abstract:
The Ce(IV)-induced hydrolyses of DNA are kinetically investigated. The formation constants of the Ce(IV)-DNA complexes are in the following order: the single-stranded DNA > the double-stranded DNA >> the dinucleotide. On the other hand, the catalytic rate constants for the single-stranded DNA and the double-stranded DNA are comparable with each other, but both of them are much smaller than the value for the dinucleotide hydrolysis.