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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: Jul 24, 2026

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

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MDR1 gene expression and outcome in osteosarcoma: a prospective, multicenter study.

J S Wunder1, S B Bull, V Aneliunas

  • 1Samuel Lunenfeld Research Institute and the University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada. wunder@mshri.on.ca

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|July 15, 2000
PubMed
Summary

Multidrug resistance gene (MDR1) mRNA expression did not correlate with osteosarcoma recurrence in a prospective study. Large tumor size was the only significant predictor of systemic outcome in patients with extremity osteosarcoma.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The multidrug resistance gene (MDR1) is implicated in osteosarcoma prognosis.
  • Assessing MDR1 mRNA expression's prognostic value in osteosarcoma is crucial for treatment strategies.

Purpose of the Study:

  • To prospectively evaluate the prognostic significance of MDR1 mRNA expression in patients with newly diagnosed extremity osteosarcoma.
  • To determine the association between MDR1 mRNA levels and the risk of systemic recurrence.

Main Methods:

  • Prospective study of 123 patients with high-grade, nonmetastatic extremity osteosarcoma treated with chemotherapy and surgery.
  • Analysis of MDR1 mRNA expression in tumor samples.
  • Survival analyses were performed to assess the relationship between MDR1 expression and systemic recurrence, considering traditional and histologic prognostic factors.

Main Results:

  • No dose-response relationship was found between MDR1 mRNA expression levels and systemic relapse (P =.44).
  • Biopsy or resection MDR1 values also showed no significant correlation with recurrence (P =.11 and.41).
  • Multivariate analysis identified large tumor size (> 9 cm) as the sole independent predictor of systemic outcome (relative risk, 2.8; P =.002).

Conclusions:

  • MDR1 mRNA expression does not correlate with disease progression in osteosarcoma.
  • Other genetic alterations likely play a more significant role in chemotherapy resistance in osteosarcoma than MDR1.