Thyroid function in haemodialysed patients of Gassim, Saudi Arabia: TRH stimulation

To study the hypophysical-pituitary-thyroid axis in Saudi patients on (RDT), 200 units of TRH were given intravenously predialysis to each of 21 such subjects. As expected (TSH) rose promptly within 30 minutes followed by a gentle decline at 60 minutes. A more gentle rise was also noted in T3 which continued for the 60 minutes of observation. Rather unexpectedly, T4 level was noted to show a reciprocal decline. To our knowledge, this pattern has not been defined in literature. In 12 patients (GH) was noted to rise promptly within 30 minutes followed by a gentle decline at 60 minutes. (LH) and (FSH) did not follow any definite pattern as observed for T3 and T4. Since the oral preparation of TRH is now available, can (TRH) be effectively used to treat renal dwarfism?