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A case report of Aspergillus hypersensitivity syndrome with obstructing bronchial aspergillosis
Annals of the Academy of Medicine, Singapore
|July 15, 2000
Abstract
Introduction:
A 62-year-old Indian male with diabetes mellitus presented with atypical, overlap features of Aspergillus hypersensitivity syndrome and obstructing bronchial aspergillosis.
Clinical Picture:
He was febrile and tachypnoeic with diffuse crepitations and wheezing. Chest X-ray was normal but eosinophil count was 2900/mm3 and Ig E > 10,000 IU/ml.
Treatment And Outcome:
He responded initially to high dose steroid therapy but deteriorated subsequently from extensive mucus plugging of the bronchial tree which resulted in respiratory failure and death. He was HIV-negative.
Conclusion:
Culture and histologic examination of bronchoscopically identified tracheobronchial mucus plugs should be performed as early treatment may be life-saving.