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Synthesis and biological activity of conformationally controlled 2-PAM derivatives
1College of Pharmacy, Yeungnam University, Kyongsan, Korea. ydjahng@ynucc.yeungnam.ac.kr
Archives of Pharmacal Research
|July 15, 2000
Abstract:
A series of conformationally controlled 2-PAM derivatives were prepared from 2-acetylpyridine and 2,3-pyrido[b]cycloalkenones in two steps and their reactivities towards parathion poisoned AChE were evaluated. The most planar 2,3-pyrido[b]cyclohexanone oxime methiodide showed an activity comparable to 2-PAM implying E-syn is that the most active conformation of 2-PAM in the biological system.