[Atypical adenomatous hyperplasia of the lung]
Related Experiment Video
Updated: Oct 15, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
O V Paklina1, G A Galil-Ogly, A M Bershchanskaia
1Russian Roentgenoradiological Research Centre, Moscow.
Abstract:
Clinicomorphological analysis was performed in 12 cases of atypical adenomatous hyperplasia of the lung (AAH). This is the proliferative lesion consisting of atypical epithelial cells along the alveolar septa which are found incidentally during pathologic examination of the lung resected because of cancer. We studied morphological and biological characteristics of AAH cells including cytodifferentiation, proliferative activity, tumor-suppressor genes. Our review of the studies of AAH revealed that AAH is alveolar intraepithelial dysplasia and a precursor of lung adenocarcinoma. AAH is an important lesion corresponding to a step in carcinogenesis for peripheral lung adenocarcinomas.
Related Concept Videos
Atypical Pneumonia
Cellular Adaptation IV: Dysplasia and Metaplasia
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Other Pulmonary Disorders