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[Blood serum hepatocyte growth factor in children with chronic renal failure treated with CAPD and HD]
K Szprynger1, M Szczepańska, A Morawiec-Knysak
1Katedry i Kliniki Nefrologii, Endokrynologii i Chorób Metabolicznych Wieku Dzieciecego w Zabrzu.
Insights
Hepatocyte growth factor (HGF) levels were highest in children on hemodialysis (HD) compared to peritoneal dialysis (CAPD) and healthy controls. No significant differences were found between HD patients and healthy children.
Area of Science:
- Nephrology
- Biochemistry
- Pediatrics
Context:
- Chronic renal failure (CRF) impacts growth and development in children.
- Dialysis treatments, including continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD), are common for pediatric CRF.
- Hepatocyte growth factor (HGF) plays a role in tissue repair and regeneration, including renal tissues.
Purpose:
- To analyze and compare serum hepatocyte growth factor (HGF) concentrations in children with chronic renal failure undergoing CAPD and HD treatments.
- To investigate potential correlations between HGF levels and clinical parameters in pediatric dialysis patients.
Summary:
- Serum HGF concentrations were measured in 20 children on CAPD, 20 on HD, and 10 healthy controls.
- Children on HD exhibited the highest HGF levels, comparable to healthy children, while CAPD patients showed lower concentrations.
- No significant correlations were found between HGF levels and dialysis duration, blood pressure, lipid profile, calcium, or hemoglobin levels.
Impact:
- Findings suggest that HD may be associated with higher HGF levels in pediatric patients with CRF.
- Lower HGF in CAPD patients might be due to factors like heparin absence or transperitoneal clearance.
- Further research with larger cohorts is needed to explore HGF clearance in CAPD patients.
Abstract:
HGF--hepatocyte growth factor--belongs to the growth factors family, derivatives of plasminogen. HGF is a potent mitogen for hepatocytes, and has also renotropic properties. The study aimed at analysing HGF serum concentration in 20 children on continuous ambulatory peritoneal dialysis (CAPD) and haemodialysis (HD) treatment. 10 healthy children served as a control group (K). CAPD group has been examined during routine monthly control, whereas HD group before a haemodialysis session. In HD treated children the highest HGF concentration was obtained in comparison to children on CAPD and control group. There was no significant difference HGF levels between children on HD and healthy ones. We found no relationship between the dialysis treatment duration, mean arterial pressure values, serum total cholesterol, triglycerides, ionised calcium concentration, haemoglobin concentration, hematocrit and serum HGF concentration. In examined group of children with chronic renal failure the highest HGF values were noted in children on HD, not strictly observing the dietetic regime and proper daily fluid intake. Diminished HGF concentration in children on CAPD could be explained by the absence of stimulating action of heparin and by transperitoneal removal of substances false by elevating HGF. It is necessary to carry out studies in larger group of children with chronic renal failure on CAPD in order to estimate transperitoneal clearance of HGF and its metabolites.