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Hodgkin's disease in association with Down syndrome: a case report
P Kusumakumary1, R Jyothirmayi, V G Chellam
1Regional Cancer Centre, Trivandrum, Kerala, India.
Abstract:
The increased incidence of malignancies, especially acute leukemia, in Down syndrome has been clearly established. The association of Hodgkin's disease with Down syndrome has not been extensively documented, and only a few cases have been reported. We present here a case report of Hodgkin's disease in an 11-year-old female child with Down syndrome. The child presented with a stage IVB nodular sclerotic Hodgkin's disease and died of progressive disease. We also present a brief review of the mechanisms of development of malignancy in Down syndrome.
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