Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Unilateral cryptophthalmia.

R O Howard, R M Fineman, B Anderson

    American Journal of Ophthalmology
    |April 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Counselling for alcohol problems in primary care in Forth Valley--an innovative approach?

    Health bulletin·2003
    Same author

    Responsiveness of the Problem Areas In Diabetes (PAID) questionnaire.

    Diabetic medicine : a journal of the British Diabetic Association·2003
    Same author

    Vagus nerve stimulation therapy: a research update.

    Neurology·2002
    Same author

    Funding cuts compromise sexual health care.

    Nursing New Zealand (Wellington, N.Z. : 1995)·2002
    Same author

    Nursing service adapts to changing needs and funding.

    Nursing New Zealand (Wellington, N.Z. : 1995)·2002
    Same author

    The public perceptions of the rewards and risks of genetic research: the Oregon story.

    Professional ethics report : newsletter of the American Association for the Advancement of Science, Committee on Scientific Freedom & Responsibility, Professional Society Ethics Group·2002
    Same journal

    Reply to Comment on Visual Field Progression in Glaucoma Patients with Delayed Follow-Up.

    American journal of ophthalmology·2026
    Same journal

    Comment on: "Safety and efficiency reducing retinopathy of prematurity guideline sensitivity: an external validation using a large US-based dataset".

    American journal of ophthalmology·2026
    Same journal

    Reply to Comment on "Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease".

    American journal of ophthalmology·2026
    Same journal

    Comment on: Visual Field Progression in Glaucoma Patients With Delayed Follow-Up.

    American journal of ophthalmology·2026
    Same journal

    Corneal sensitivity changes and nerve plexus abnormalities in noninfectious anterior uveitis.

    American journal of ophthalmology·2026
    Same journal

    Role of Menopausal Hormone Therapy on Strabismus, Strabismus Surgery, and Reoperation Rates.

    American journal of ophthalmology·2026
    See all related articles

    Unilateral cryptophthalmia presents with varied clinical features. This condition involves developmental abnormalities of the eye and orbit, sometimes associated with systemic issues.

    Area of Science:

    • Ophthalmology
    • Medical Genetics
    • Developmental Biology

    Background:

    • Cryptophthalmia is a rare congenital anomaly characterized by the absence of an eyelid.
    • Unilateral cryptophthalmia, affecting one eye, is exceptionally rare and poorly understood.
    • This study examines two distinct cases to elucidate the spectrum of this condition.

    Observation:

    • A 5-month-old boy presented with isolated unilateral cryptophthalmia, featuring a malformed orbit and ocular structures without identifiable intraocular tissue, optic nerve, or extraocular muscles.
    • A 13-year-old girl exhibited unilateral cryptophthalmia alongside significant systemic abnormalities, including microcephaly, severe intellectual disability, facial clefting, and limb contractures.
    • Advanced imaging techniques like B-scan ultrasound and computed tomography confirmed the absence of normal ocular structures in both patients.

    Related Experiment Videos

    Findings:

    • Both patients displayed severe ocular and orbital malformations consistent with unilateral cryptophthalmia.
    • The case of the young boy highlights isolated ocular-vestigial findings.
    • The young girl's presentation underscores the potential for cryptophthalmia to be part of a broader genetic syndrome with multisystem involvement.

    Implications:

    • These cases expand the understanding of the clinical variability of unilateral cryptophthalmia.
    • Further research into the genetic and developmental pathways underlying cryptophthalmia is warranted.
    • Recognizing associated systemic abnormalities is crucial for comprehensive patient management and genetic counseling.