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[Glucocorticosteroids in bacterial endocarditis: is it beneficial or harmful?]
Aim:
Analysis of results of treatment of infectious endocarditis (IE) with glucocorticosteroids in combination with antibiotics.
Material And Methods:
128 IE patients received antibiotics (control group). Glucocorticosteroids were added to antibiotics in 44 IE patients (study group).
Results:
Valvular replacement, congestive heart insufficiency, thromboembolic complications, suppression of cellular and humoral immunity occurred more frequently in patients of the study group.
Conclusion:
It was found that glucocorticosteroids affect IE negatively, especially in the dose 30 mg/day and higher. Glucocorticosteroids are indicated in allergic reactions to the antibacterial drugs, severe renal damage (proteinuria < 1 g/l), myocardial defects; contraindicated in non-eradicated IE causative agent, in recurrent IE.