[Immunogenetic aspects in pathogenesis of acute pancreatitis]

Acute pancreatitis is characterized by essential decrease of the activity of the complement C1-C5 system components which is more marked under destructive form of the disease. The increased consumption of the components of the complement may be determined by forming immune complexes under interaction of the antibodies with structural and secretory components of the pancreas and direct proteolytic conversion under influence of trypsin. The revealed associations with HLA I antigens suggest the presence of genetic determination of the changes in the complement system. It may be also possible that components of the complement system, in particular C4 which is immune product of the HLA class III region, exert regulating influence on humoral immune reactions in acute pancreatitis.