[Parameters of lipid metabolism during perimenopause and thyroid pathology]

A total of 210 perimenopausal women were examined. Lipid status was evaluated in groups of patients differing by thyroid function and characteristics of the perimenopausal period. Case histories were analyzed using a universal information chart. Serum levels of T3, T4, TTH, LH, FSH, PRL, E2, and progesterone were radioimmunoassayed. Blood lipid spectrum was evaluated on a Kone device (Finland) by special standard methods. High levels of cholesterol and triglycerides, a tendency to an increase in CH-LDL and CH-VLDL, a decrease in CH-HDL, and a high atherogenicity coefficient were detected in women with endemic goiter and hypothyrosis in comparison with perimenopausal women without thyroid disease. The highest levels of cholesterol, triglycerides, CH-LDL, and atherogenicity coefficient were detected in women with endemic goiter and climacteric syndrome, which suggests that hypothyrosis in the presence of climacteric syndrome aggravates disordered lipid metabolism.