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Microsatellites in the HLA region: 1999 update
A Foissac1, M Salhi, A Cambon-Thomsen
1Inserm U518, Epidémiologie et Analyses en Santé publique: Risques, maladies chroniques et handicaps, Faculté de Médecine, Toulouse, France.
Tissue Antigens
|July 21, 2000
Summary
This review updates the microsatellite markers in the Human Leukocyte Antigen (HLA) region, detailing 155 markers. It provides a valuable resource for selecting microsatellites in immunogenetics and disease genetics studies.
Area of Science:
- Human Immunogenetics
- Molecular Biology
- Genetics
Background:
- Microsatellites in the Human Leukocyte Antigen (HLA) region are crucial genetic markers.
- Previous reviews in 1997 and 1998 documented existing microsatellites.
- The Major Histocompatibility Complex (MHC) is a highly polymorphic region with significant genetic implications.
Purpose of the Study:
- To provide an updated compilation of microsatellites within or near the HLA region.
- To offer a comprehensive resource for researchers in human immunogenetics.
- To facilitate the selection of appropriate microsatellites for various genetic studies, particularly in disease genetics.
Main Methods:
- Literature review of scientific publications up to September 1999.
- Analysis of publicly available data from molecular databases (GDB, WEIZMANN, SOTON).
- Compilation and organization of data including marker location, polymorphism, and amplification conditions.
Main Results:
- Identification and description of 155 microsatellites in the HLA region, including 51 newly reported markers.
- Presentation of a table detailing marker characteristics (name, localization, polymorphism, primers, references).
- Integration of an HLA region gene map with the identified microsatellites and a summary of HLA-microsatellite association patterns.
Conclusions:
- This review serves as an essential tool for the human immunogenetics community.
- The updated information aids in the optimal selection of HLA microsatellites for research.
- The resource supports ongoing studies in disease genetics utilizing HLA region markers.