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Experimental carinal replacement with an Y-shaped collagen-conjugated prosthesis
T Sekine1, T Nakamura, Y Shimizu
1Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, Japan. sekine@frontier.kyoto-u.ac.jp
The Thoracic and Cardiovascular Surgeon
|July 21, 2000
Summary
This study introduces a novel Y-shaped prosthesis for tracheal carinal reconstruction in dogs. Promising results indicate potential for successful prosthetic carinal replacement with epithelial regrowth.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Veterinary Surgery
Background:
- Tracheal carinal reconstruction presents surgical challenges.
- A novel Y-shaped prosthesis was developed for experimental carinal replacement.
Purpose of the Study:
- To evaluate the efficacy and biocompatibility of a new Y-shaped prosthesis for tracheal carinal reconstruction.
- To assess the potential for epithelial regrowth and long-term success in prosthetic carinal replacement.
Main Methods:
- A Y-shaped Marlex mesh tube prosthesis, reinforced with polypropylene spirals and coated with porcine collagen, was designed.
- Carinal replacement surgery using the prosthesis and omentopexy was performed in 17 dogs.
Main Results:
- Seven dogs survived the early postoperative period; 10 died from complications like fistula and air leakage.
- Late complications included bronchial obstruction and lung abscess.
- Four long-term survivors showed no stenosis or dehiscence, with histological evidence of luminal epithelial coverage.
Conclusions:
- The Y-shaped prosthesis demonstrates potential for successful prosthetic carinal reconstruction.
- Epithelial regrowth on the prosthesis surface suggests good biocompatibility and integration.