Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Competence, specification and commitment in otic placode induction.

A K Groves1, M Bronner-Fraser

  • 1Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. agroves@hei.org

Development (Cambridge, England)
|July 21, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Navigating trauma: Venezuelan women's and adolescent's experiences before and after migration amidst the humanitarian crisis.

Journal of migration and health·2025
Same author

Barriers and facilitators to HIV prevention and care for Venezuelan migrant/refugee women and girls in Colombia.

Journal of migration and health·2023
Same author

Soliciting parental consent among adolescent minor mothers: A barrier in adolescent HIV research?

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021
Same author

When do adolescent mothers return to school? Timing across rural and urban South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2020
Same author

A critical role for Cadherin6B in regulating avian neural crest emigration.

Developmental biology·2007
Same author

Characterization of chicken Nf2/merlin indicates regulatory roles in cell proliferation and migration.

Developmental dynamics : an official publication of the American Association of Anatomists·2004
Same journal

Expanding the C. elegans toolkit with gonad explants.

Development (Cambridge, England)·2026
Same journal

Nuclear Factor Y controls nutrient-adaptive epithelial growth by regulating mTOR in the Drosophila midgut.

Development (Cambridge, England)·2026
Same journal

Primordial germ cells differentially contribute to the germline in zebrafish.

Development (Cambridge, England)·2026
Same journal

Dissecting planar and vertical organiser signals in early chick neural development.

Development (Cambridge, England)·2026
Same journal

Real-time transcriptomic profiling of hPSC-derived cartilage during development identifies a key role for the extracellular matrix in homeostasis and protection.

Development (Cambridge, England)·2026
Same journal

In preprints - housekeeping the housekeeping genes.

Development (Cambridge, England)·2026
See all related articles

This study identifies four key genes (Pax-2, Sox-3, BMP-7, Notch) involved in early inner ear development. These molecular markers reveal otic placode specification and commitment occur earlier than previously understood.

Area of Science:

  • Developmental biology
  • Molecular genetics
  • Neuroscience

Background:

  • Inner ear induction from cranial ectoderm is crucial for auditory and vestibular function.
  • The precise molecular mechanisms governing inner ear induction have remained largely unknown for decades.

Purpose of the Study:

  • To identify early molecular markers for inner ear induction.
  • To determine the timing of otic placode specification and commitment.
  • To map the location and persistence of otic placode-inducing activity.

Main Methods:

  • Utilized four molecular markers (Pax-2, Sox-3, BMP-7, Notch) expressed in the early otic placode.
  • Analyzed gene expression patterns at different embryonic stages (somite stages).
  • Performed embryonic tissue transplantation to assess competence and inducing activity.

Related Experiment Videos

Main Results:

  • Identified Pax-2, Sox-3, BMP-7, and Notch as early molecular markers for the otic placode, present from 4-5 somite stages.
  • Demonstrated otic placode specification occurs at 4-6 somite stages and commitment by 10 somite stages.
  • Showed broad embryonic ectoderm competence for otic placode formation and identified the rostrocaudal distribution of inducing activity persisting until at least 10 somite stages.

Conclusions:

  • Inner ear induction in birds occurs in a stepwise, independently regulated manner, earlier than previously thought.
  • Early molecular markers provide critical insights into the initial stages of inner ear development.
  • Understanding these early events is fundamental for deciphering the complex process of inner ear formation.