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1Centre de pneumologie de l'Hôpital Laval, Université Laval, Sainte-Foy, Canada.
Canadian Respiratory Journal
|July 21, 2000
Summary
Twice-daily fluticasone propionate (FP) showed greater efficacy than once-daily FP for mild to moderate asthma. However, once-daily FP dosing still maintained asthma control in most patients.
Area of Science:
- Pulmonology
- Pharmacology
- Clinical Medicine
Background:
- Asthma management often involves inhaled corticosteroids like fluticasone propionate (FP).
- Optimal dosing frequency for FP in mild to moderate asthma requires further investigation.
Purpose of the Study:
- To compare the efficacy and safety of once-daily versus twice-daily fluticasone propionate (FP) dosing.
- To evaluate FP's effectiveness in mild to moderate asthma patients requiring 200 or 500 µg daily.
Main Methods:
- Two 12-week, randomized, double-blind, parallel-group studies were conducted.
- Study A: 461 patients received FP 200 µg once daily or 100 µg twice daily.
- Study B: 443 patients received FP 500 µg once daily or 250 µg twice daily.
Main Results:
- Both regimens showed small improvements in peak expiratory flow (PEF) and forced expiratory volume in 1 s (FEV1).
- Twice-daily FP demonstrated statistically significant improvements in PEF over once-daily dosing in both studies.
- Asthma exacerbation rates were generally comparable, with some trends suggesting lower rates with twice-daily dosing.
Conclusions:
- Twice-daily fluticasone propionate (FP) dosing is more effective than once-daily dosing for mild to moderate asthma.
- Once-daily FP can maintain asthma control in a majority of patients.
- Both dosing regimens were generally well-tolerated with comparable safety profiles.
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