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Related Experiment Videos

Robust charge transport in DNA double crossover assemblies.

D T Odom1, E A Dill, J K Barton

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena 91125, USA.

Chemistry & Biology
|July 25, 2000
PubMed
Summary
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DNA double crossover (DX) assemblies facilitate selective, long-range charge transport through base stacking, acting as insulated conduits for nanoscale electronic devices.

Area of Science:

  • Molecular nanotechnology
  • DNA self-assembly
  • Charge transport mechanisms

Background:

  • DNA assemblies are explored for self-assembling nanodevices.
  • DNA exhibits semiconductor properties, enabling charge transport.
  • Oxidative damage in DNA can occur via charge transport.

Purpose of the Study:

  • Design a DNA double crossover (DX) assembly for charge transport studies.
  • Investigate charge transport through DNA DX assemblies.
  • Probe the role of guanine and photo-oxidants in DNA charge transport.

Main Methods:

  • Constructed a DNA DX assembly with oxidatively sensitive guanine.
  • Tethered a rhodium photo-oxidant to probe charge transport.
  • Analyzed charge transport selectivity and disruption in DX assemblies versus duplex DNA.

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Main Results:

  • DX assemblies support selective long-range charge transport down the base stack.
  • Electron transfer (ET) crossover to adjacent stacks was not observed.
  • DX assemblies showed reduced susceptibility to stacking perturbations compared to duplex DNA.

Conclusions:

  • Base stacking dictates the charge transport path in DX DNA assemblies.
  • Closely packed stacks in DX assemblies are electronically insulated.
  • DX DNA assemblies are robust, insulated conduits for nanoscale charge transport.