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Emx homeogenes and mouse brain development.

C Cecchi1, E Boncinelli

  • 1Molecular Developmental Biology Unit, DIBIT, Istituto Scientifico H San Raffaele, 20132 Milan, Italy.

Trends in Neurosciences
|July 25, 2000
PubMed
Summary
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Mammalian Emx2 homeogenes are crucial for developing the cerebral cortex and rostral brain patterning. Studies reveal Emx2

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Mammalian Emx homeogenes (Emx1, Emx2) are expressed during cerebral cortex development.
  • Emx1 function remains largely unknown, while Emx2's role is increasingly understood through mouse models.

Purpose of the Study:

  • To elucidate the function of the Emx2 homeogene in the developing mammalian brain.
  • To investigate the role of Emx2 in cortical patterning and neuronal migration.

Main Methods:

  • Analysis of cortical phenotypes in normal and mutant mice.
  • Examination of Emx2 expression patterns in developing cortical cells.

Main Results:

  • Emx2 is expressed in proliferating neuroblasts and postmitotic Cajal-Retzius cells.

Related Experiment Videos

  • Cajal-Retzius cells are known to regulate cortical neuron migration.
  • The graded distribution of Emx2 protein suggests a role in cortical subdivision.

    • Conclusions:

    • Emx2 plays a significant role in the patterning and organization of the developing cerebral cortex.
    • Emx2 may be involved in establishing distinct territories and areas within the cortex.