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Updated: Aug 17, 2026

Chromatin Immunoprecipitation Assay Using Micrococcal Nucleases in Mammalian Cells
Published on: May 10, 2019
Mammalian chitinase-like proteins
G Bleau1, F Massicotte, Y Merlen
1Département d'Obstétrique-Gynécologie, Centre Hospitalier de l'Université de Montréal, Hôpital Saint-Luc, Québec, Canada.
Abstract:
Mammals express genes coding for proteins that show significant similarity to chitinases of family 18 glycosyl hydrolases. These chitinase-like proteins have no chitinase activity due to changes in critical residues in the putative active center. One of these is oviductin, a high molecular weight glycoprotein most likely involved in fertilization and protection of the tubal epithelium owing to its mucin character. Another is YKL-40 (HCgp39) produced in association with tissue remodeling. Such proteins could have a general function in morphogenesis.
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