Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microparticulate drug delivery systems.

I Genta1, P Perugini, F Pavanetto

  • 1Department of Pharmaceutical Chemistry, University of Pavia, Italy.

EXS
|July 25, 2000
PubMed
Summary

Chitosan shows promise as a biodegradable drug carrier for mucosal delivery, enhancing drug absorption. Research explores its use in ocular, nasal, and oral therapies, including vaccine delivery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating electrospun shape memory patches as Gentamicin drug delivery system.

International journal of pharmaceutics·2025
Same author

CTNND1-Related Disorder: New Insight on Prenatal Phenotype.

American journal of medical genetics. Part A·2024
Same author

Effect of different diet composition on the fat profile of two different black soldier fly larvae populations.

Animal : an international journal of animal bioscience·2024
Same author

Cellulose Acetate Trimellitate Microspheres Containing NSAIDS.

Drug development and industrial pharmacy·2023
Same author

[Cholelithiasis and cholecystectomy in infants].

Revue medicale de Liege·2022
Same author

Author Correction: Essential oils sensory quality and their bioactivity against the mosquito Aedes albopictus.

Scientific reports·2019

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Chitosan, a biodegradable polymer, possesses inherent bioadhesive properties suitable for drug delivery.
  • Its biodegradability in vivo is mediated by hydrolases, making it a candidate for mucosal administration.
  • Applications include ocular, buccal, nasal, gastroenteric, and vaginal-uterine drug delivery.

Purpose of the Study:

  • To evaluate chitosan as a drug carrier for various mucosal administration routes.
  • To investigate methods for controlling chitosan microparticle degradation, particularly in acidic environments.
  • To assess the suitability of chitosan for oral vaccine delivery.

Main Methods:

  • Review of existing literature on chitosan-based drug delivery systems.

Related Experiment Videos

  • Analysis of chitosan's bioadhesive and biodegradability characteristics.
  • Discussion of cross-linking techniques and their impact on chitosan properties.

    • Main Results:

    • Chitosan facilitates drug delivery, exemplified by acyclovir (ocular) and 5-aminosalicylic acid (colonic).
    • Cross-linking is necessary to prevent degradation in acidic media but glutaraldehyde cross-linking introduces cytotoxicity and reduces bioadhesion.
    • Alternative cross-linking methods are being explored to mitigate these issues.

    Conclusions:

    • Chitosan is a versatile biomaterial for mucosal drug delivery due to its bioadhesion and biodegradability.
    • Careful consideration of cross-linking strategies is crucial to optimize chitosan-based drug carriers.
    • Chitosan holds potential for oral vaccine delivery, warranting further investigation.