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IB-96212, a novel cytotoxic macrolide produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation and
R I Fernández-Chimeno1, L Cañedo, F Espliego
1Drug Discovery Division, PharmaMar, SA La Calera, Madrid, Spain.
The Journal of Antibiotics
|July 25, 2000
Abstract:
A novel bioactive macrolide, IB-96212 has been isolated from the fermentation broth of a marine actinomycete, L-25-ES25-008. The strain belongs to the genus Micromonospora. The macrolide showed a very strong cytotoxic activity against P-388, and lower but significant activity against A-549, HT-29, and MEL-28 cell lines. We describe the isolation, taxonomy and fermentation of the producing strain as well as the isolation of IB-96212.