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Related Experiment Videos

Methylchloro-isothiazolinone revisited.

C M Mowad1

  • 1Penn State College of Medicine, Geisinger Medical Center, Danville, PA 17821, USA. cmowad@psghs.edu

American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society
|July 25, 2000
PubMed
Summary

Preservatives are common allergens found in patch testing. Methylchloroisothiazolinone/methylisothiozolinone (MCI/MI) is a widely used preservative, and its sensitivity rates are comparable to other allergens in its class.

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Area of Science:

  • Dermatology
  • Allergology
  • Contact Dermatitis

Background:

  • Preservatives represent a significant category of allergens frequently included in diagnostic testing series.
  • Various preservative concentrations are present in common patch test kits, including the TRUE test, European series, and North American Series.
  • Methylchloroisothiazolinone/methylisothiozolinone (MCI/MI) emerged as a notable preservative allergen in the 1980s.

Purpose of the Study:

  • To evaluate the prevalence and significance of preservatives, particularly MCI/MI, within standard allergy testing protocols.
  • To understand the trends in MCI/MI usage and reported contact allergies.
  • To compare the sensitivity rates of MCI/MI with other common preservative allergens.

Main Methods:

  • Analysis of preservative content in major patch testing series (TRUE test, European, North American).

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  • Review of literature and data regarding the introduction and use of MCI/MI.
  • Examination of reported incidence rates of contact allergy to MCI/MI, referencing data from the North American Contact Dermatitis Group.

    • Main Results:

    • The study highlights the substantial representation of preservatives within allergy testing.
    • Methylchloroisothiazolinone/methylisothiozolinone (MCI/MI) has seen increased use since its introduction, leading to concerns about contact allergy.
    • Reported sensitivity rates for MCI/MI are comparable to other preservatives, despite variations in allowable product levels and usage rates across countries.

    Conclusions:

    • Preservatives are a key group of allergens necessitating inclusion in diagnostic testing.
    • MCI/MI, while a relatively recent addition, has become a significant contact allergen.
    • The incidence of MCI/MI sensitivity aligns with that of other common preservatives, underscoring the importance of awareness and appropriate product formulation.