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Related Experiment Videos

Physiological and pathological tremors and rhythmic central motor control.

J H McAuley1, C D Marsden

  • 1Human Movement and Balance Unit, Institute of Neurology, London, UK. jhmcauley@clara.co.uk

Brain : a Journal of Neurology
|July 25, 2000
PubMed
Summary

Physiological tremor offers a window into central nervous system (CNS) oscillations, revealing multifactorial origins including CNS activity, motor unit properties, and reflex loops. Pathological tremors may stem from distorted physiological components or novel central oscillations.

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Area of Science:

  • Neuroscience
  • Motor Control
  • Biophysics

Background:

  • Increasing interest in central nervous system (CNS) oscillatory neural activity and its role in motor control.
  • Physiological tremor is hypothesized to reflect peripheral manifestations of central oscillatory activity.
  • Pathological tremors may result from disruptions in these central oscillators.

Purpose of the Study:

  • To re-evaluate studies on physiological and pathological tremors and peripheral oscillations.
  • To gain a new perspective on the nature and function of central oscillatory progenitors.
  • To utilize tremor as a 'window' into the function of CNS oscillations for human investigations.

Main Methods:

  • Review of early and recent studies on physiological and pathological tremors.

Related Experiment Videos

  • Analysis of peripheral oscillations as indirect indicators of central oscillatory activity.
  • Comparative analysis of different tremor types and their potential central origins.

    • Main Results:

    • Physiological tremor is likely multifactorial, involving CNS 10-Hz oscillations, motor unit properties, and reflex/mechanical resonances.
    • Some pathological tremors distort physiological components; others, like 3-6 Hz parkinsonian tremor, arise de novo.
    • CNS oscillations outside the 10-Hz range modulate limb activity; oscillations also exist in other motor systems (e.g., eye movements).

    Conclusions:

    • Peripheral oscillations provide insights into CNS oscillatory roles in motor control.
    • Hypotheses include the 'binding' function of synchronized oscillations and frequency coding of motor signals.
    • Understanding tremor mechanisms can illuminate fundamental principles of neural control and coordination.