Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basic fibroblast growth factor (bFGF) in saliva--physiological and clinical implications.

H Ishizaki1, A Westermark, G van Setten

  • 1Department of Otolaryngology, Karolinska Institute, Stockholm, Sweden.

Acta Oto-Laryngologica. Supplementum
|July 26, 2000
PubMed
Summary

Basic fibroblast growth factor (bFGF) aids wound healing. This study found bFGF in all healthy saliva samples, with higher levels in smokers, suggesting a role in mucous membrane repair.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of COVID-19 screening for international travellers.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2022
Same author

Imaging of Temporal Bone.

Advances in oto-rhino-laryngology·2019
Same author

Changes in the expression of α-tocopherol-related genes in liver and mammary gland biopsy specimens of peripartum dairy cows.

Journal of dairy science·2018
Same author

Pan-European survey of the topical ocular use of cyclosporine A.

Journal francais d'ophtalmologie·2017
Same author

Postweaning changes in the expression of chemerin and its receptors in calves are associated with the modification of glucose metabolism.

Journal of animal science·2016
Same author

Expression of α-tocopherol-associated genes and α-tocopherol accumulation in Japanese Black (Wagyu) calves with and without α-tocopherol supplementation.

Journal of animal science·2015

Area of Science:

  • Biochemistry
  • Regenerative Medicine
  • Oral Biology

Background:

  • Basic fibroblast growth factor (bFGF) is crucial for wound healing, tissue regeneration, and ulcer repair.
  • Understanding bFGF levels in saliva can provide insights into oral mucosal health.
  • Previous research has established the role of bFGF in various physiological processes.

Purpose of the Study:

  • To identify and analyze factors influencing basic fibroblast growth factor (bFGF) concentration in saliva from healthy individuals.
  • To establish baseline levels of bFGF in a healthy human cohort.
  • To explore potential correlations between bFGF levels and demographic factors or lifestyle choices.

Main Methods:

  • Saliva samples were collected from 28 healthy subjects (15 male, 13 female).

Related Experiment Videos

  • Basic fibroblast growth factor (bFGF) concentrations were quantified using a commercially available enzyme-linked immunosorbent assay (ELISA) kit.
  • Spectrophotometry at a wavelength of 490 nm was used for bFGF determination.

    • Main Results:

    • Basic fibroblast growth factor (bFGF) was detected in all analyzed saliva samples.
    • The mean bFGF concentration was 0.87 pg/ml (SD 0.49), with a range of 0.3 to 1.9 pg/ml.
    • Smokers exhibited significantly higher saliva bFGF concentrations compared to non-smokers. No significant differences were observed based on age, sex, or ethnicity.

    Conclusions:

    • Salivary basic fibroblast growth factor (bFGF) is present in healthy individuals.
    • Higher bFGF levels in smokers may indicate an increased need for tissue repair or a response to smoking-induced damage.
    • The presence and potential role of bFGF in saliva suggest its involvement in the reparative processes of oral mucous membranes.