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Updated: Sep 21, 2026

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
Published on: January 26, 2018
[Effect of the dopamine antagonist metoclopramide on uterine contraction]
Background:
Because of its activity on the gastro-intestinal tract metoclopramide is used also in pregnancy, though nothing is known about its effect on the pregnant uterus. Therefore it was of interest to look after a change in uterine activity after the application of metoclopramide in a clinical relevant dose.
Materials And Methods:
24 strips from pregnant uteri were removed during a cesarean section, brought into an organ chamber and changes of spontaneous activity after the application of metoclopramide were measured.
Results:
A highly significant decrease of uterine activity was observed.
Conclusions:
It was demonstrated that metoclopramide, in contrast to stomach and ureter, exerts not a tonifying but a relaxant effect on the uterus.
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