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[Intravenous lignocaine for chronic pain: an 18-month experience]
A Cahana1, V Shvelzon, O Dolberg
1Pain Treatment Services, Dept. of Anesthesiology of Sheba Medical Center, University Hospital, Jerusalem.
Harefuah
|July 26, 2000
Summary
Intravenous lignocaine injections effectively relieved neuropathic pain in most patients. This treatment demonstrated significant efficacy and safety, offering lasting pain relief with no major side effects.
Area of Science:
- Anesthesiology
- Neurology
- Pharmacology
Background:
- Neuropathic pain is a challenging condition often inadequately managed by conventional therapies.
- Intravenous lignocaine has shown promise in preclinical models for pain relief.
Purpose of the Study:
- To evaluate the efficacy and safety of intravenous lignocaine for neuropathic pain.
- To assess the duration of pain relief and side effects associated with this treatment.
Main Methods:
- A prospective study involving 106 patients with neuropathic pain.
- Treatment consisted of an intravenous bolus of lignocaine (1 mg/kg) followed by a 1-hour infusion (5 mg/kg/hr).
- Continuous monitoring of blood pressure, heart rate, and pain scores was performed.
Main Results:
- Significant pain relief was observed in the majority of patients after each treatment session.
- Pain relief duration varied from a few hours to 4 weeks.
- No significant adverse events were reported during the study.
Conclusions:
- Intravenous lignocaine is a simple, effective, and safe option for managing neuropathic pain.
- It is particularly recommended for patients whose pain is not adequately controlled by existing treatments.
- Further investigation into long-term outcomes may be warranted.