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Related Experiment Videos

Acute fatty liver in the second trimester.

M Monga1, A R Katz

  • 1Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Medical School Houston, 77030, USA. mmonga@obg.med.uth.tmc.edu

Obstetrics and Gynecology
|July 27, 2000
PubMed
Summary

Acute fatty liver of pregnancy, a rare condition, can occur in the second trimester, not just the third. This case highlights the importance of considering this diagnosis earlier in pregnancy.

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Area of Science:

  • Obstetrics and Gynecology
  • Hepatology
  • Maternal-Fetal Medicine

Background:

  • Acute fatty liver of pregnancy (AFLP) is a rare but serious condition typically seen in late pregnancy or postpartum.
  • Early diagnosis and management are crucial for maternal and fetal outcomes.

Observation:

  • A 35-year-old woman presented at 22 weeks' gestation with nonspecific symptoms like nausea and vomiting.
  • Progressive liver dysfunction, jaundice, altered mental status, and coagulopathy developed over 12 days.

Findings:

  • The patient was diagnosed with acute fatty liver of pregnancy during the second trimester.
  • Prompt delivery led to rapid clinical improvement, confirming the diagnosis.

Implications:

Related Experiment Videos

  • This case expands the known gestational window for AFLP presentation.
  • Clinicians should maintain a high index of suspicion for AFLP even in the second trimester.
  • Timely intervention, including delivery, is critical for managing AFLP.