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Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues
M A deLong1, J Amburgey, C Taylor
1Procter & Gamble Pharmaceuticals, Mason, OH 45040, USA. delong.ma@pg.com
Bioorganic & Medicinal Chemistry Letters
|July 29, 2000
Abstract:
The in vitro evaluation of a series of saturated prostaglandins revealed that compounds with omega chain aromatic rings retain nanomolar potency for the human prostaglandin F receptor (hFP receptor), exemplified by compound 8. In contrast, the double bonds are required for activity in the series with an acyclic omega chain as in PGF2alpha.