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Updated: Sep 1, 2026

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
Sophisticated medical devices as local drug-delivery systems
1Institute for Scientific Evaluation of Naturopathy, University of Cologne, Germany.
Abstract:
The sustained release of antimicrobial substances from catheters, endoprostheses, wound-dressings and arterial grafts may be prudent for the prevention of device-associated infections. The release of heparin, synthetic prostacycline, hirudin and anti-inflammatory dexamethasone and related compounds from stent coatings may further reduce the risk of thrombosis, intimal hyperplasia and the requirement for long-term anticoagulation treatments. The delivery of cytokines and growth factors from wound dressings and bone grafts may accelerate wound healing and implant integration.
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