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1Target Quest BV, a subsidiary of Dyax Corp, PO Box 5800, 6202 AZ Maastricht, The Netherlands. hhoogenboom@targetquest.nl
Immunology Today
|August 1, 2000
Summary
Phage display technology enables the creation of high-affinity, fully human antibodies for therapeutic use. This review highlights its applications in antibody engineering and development.
Area of Science:
- Biotechnology
- Immunology
- Molecular Biology
Background:
- The development of fully human antibodies is crucial for advancing human therapeutics.
- Phage display technology has emerged as a powerful tool in antibody engineering.
Purpose of the Study:
- To review the application of phage display technology in developing fully human antibodies.
- To highlight other antibody engineering possibilities offered by phage display.
Main Methods:
- Phage display technology for antibody selection and engineering.
- Review of existing literature and applications.
Main Results:
- Phage display enables the generation of high-affinity, fully human antibodies.
- The technology offers diverse avenues for antibody engineering.
Conclusions:
- Phage display is a key technology for therapeutic antibody development.
- Its versatility extends to various antibody engineering strategies.