Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calciphylaxis.

L S Ledbetter1, M R Khoshnevis, S Hsu

  • 1Dermatology Department, Baylor College of Medicine, Houston, Texas 77030, USA.

Cutis
|August 5, 2000
PubMed
Summary
This summary is machine-generated.

Calciphylaxis, a rare condition causing metastatic calcification often seen in end-stage renal disease, presents with painful skin lesions. Its exact cause remains unclear, and current treatments show limited effectiveness.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The risk of developing Kaposi sarcoma after a primary malignancy: A surveillance, epidemiology and end results-based analysis.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

Comparable efficacy and safety of brodalumab in obese and nonobese patients with psoriasis: analysis of two randomized controlled trials.

The British journal of dermatology·2019
Same author

Use of dupilumab in patients who are HIV-positive: report of four cases.

The British journal of dermatology·2019
Same author

Efficacy and safety of brodalumab in patients with psoriasis who had inadequate responses to ustekinumab: subgroup analysis of two randomized phase III trials.

The British journal of dermatology·2018
Same author

Improvement in itch and other psoriasis symptoms with brodalumab in phase 3 randomized controlled trials.

Journal of the European Academy of Dermatology and Venereology : JEADV·2018
Same author

MRI-guided radiotherapy for head and neck cancer: initial clinical experience.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2017
Same journal

Black Dots on the Scalp of a Child.

Cutis·2026
Same journal

Psoriasis and Obesity: A Clinical Review of the Bidirectional Link and Management Implications.

Cutis·2026
Same journal

Adalimumab in Lichen Planus: A Narrative Review of Treatment and Paradoxical Reactions.

Cutis·2026
Same journal

The Future of Psoriasis Care.

Cutis·2026
Same journal

Evaluating GPT-4o for Automated Classification of Skin Lesions Using the HAM10000 Dataset.

Cutis·2026
Same journal

Metastatic Primary Extramammary Paget Disease: A Case Series.

Cutis·2026
See all related articles

Area of Science:

  • Nephrology
  • Dermatology
  • Pathology

Background:

  • Calciphylaxis is a rare, severe condition characterized by metastatic calcification.
  • It is most frequently observed in patients with end-stage renal disease (ESRD).
  • The precise etiology of calciphylaxis is not fully understood, with several hypotheses proposed.

Observation:

  • Clinical presentation includes painful, reticulated, purple plaques on the abdomen, buttocks, or thighs.
  • These cutaneous lesions frequently ulcerate, increasing the risk of infection.
  • Histological findings show medial calcification and intimal proliferation in small subcutaneous vessels.

Findings:

  • The study discusses the clinical features, pathophysiology, and histology of calciphylaxis.
  • It highlights the characteristic skin manifestations and microscopic changes.

Related Experiment Videos

  • The case report aims to shed light on this complex condition.

    • Implications:

    • Understanding calciphylaxis pathophysiology is crucial for developing effective treatments.
    • Early diagnosis and management may improve patient outcomes.
    • Further research is needed to elucidate the underlying mechanisms and optimize therapeutic strategies.