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Risperidone for the treatment of stuttering
G A Maguire1, G D Riley, D L Franklin
1Department of Psychiatry, University of California, Irvine, California, USA.
Journal of Clinical Psychopharmacology
|August 5, 2000
Summary
Risperidone shows promise for treating developmental stuttering in adults. This study found significant reductions in stuttering severity with risperidone compared to placebo, warranting further investigation.
Area of Science:
- Neurology
- Psychiatry
- Speech-Language Pathology
Background:
- Developmental stuttering is a complex speech disorder affecting adults.
- Current treatment options for developmental stuttering have limited efficacy.
- Risperidone, an atypical antipsychotic, has not been extensively studied for stuttering.
Purpose of the Study:
- To evaluate the efficacy of risperidone in treating developmental stuttering in adults.
- To compare the effects of risperidone versus placebo on stuttering severity measures.
Main Methods:
- A randomized, double-blind, placebo-controlled trial involving 16 adult participants.
- Participants received either placebo or risperidone (0.5 mg to 2 mg daily) for 6 weeks.
- Stuttering severity was assessed using multiple measures, including percentage of syllables stuttered.
Main Results:
- The risperidone group demonstrated significantly greater decreases in stuttering severity compared to the placebo group (p < 0.05).
- Significant reductions in percentage of syllables stuttered, speaking time percentage, and overall severity were observed in the risperidone group (p < 0.01).
- Individual responses to risperidone varied, with some patients responding best to lower doses.
Conclusions:
- Risperidone may be an effective treatment for developmental stuttering in adults.
- The findings suggest a potential role for risperidone in speech disorder management.
- Larger clinical trials are needed to confirm these preliminary results and establish optimal dosing.
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