Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

beta-hydroxy-beta-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk

S Nissen1, R L Sharp, L Panton

  • 1Iowa State University, Ames, USA.

The Journal of Nutrition
|August 5, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Intensive Training on Prolactin Responses to Submaximal Exercise in Males.

The Journal of the Iowa Academy of Science : JIAS·2026
Same author

Use of deep learning-accelerated T2 TSE for prostate MRI: Comparison with and without hyoscine butylbromide admission.

Magnetic resonance imaging·2025
Same author

EFFECT OF MENSTRUAL CYCLE PHASE ON THE GLUCOSE-INSULIN RELATIONSHIP AT REST AND DURING EXERCISE.

Biology of sport·2021
Same author

Soleus muscle stability in wild hibernating black bears.

American journal of physiology. Regulatory, integrative and comparative physiology·2018
Same author

Outcome of Neonates with Meconium Aspiration Syndrome at the University Hospital of the West Indies, Jamaica: A Resource-Limited Setting.

American journal of perinatology·2017
Same author

Attenuated improvements in adiponectin and fat loss characterize type 2 diabetes non-remission status after bariatric surgery.

Diabetes, obesity & metabolism·2014
Same journal

Microbial-derived polyphenol metabolites and the gut microbiota: A scoping review of clinical studies.

The Journal of nutrition·2026
Same journal

Hesperidin as an Emerging Nutraceutical in Modern Health and Preventive Medicine: A Narrative Review.

The Journal of nutrition·2026
Same journal

Short-Chain Fatty Acids in Livestock and Aquatic Animals: Metabolic Divergence, Physiological Functions, and Product Development.

The Journal of nutrition·2026
Same journal

Immunomodulatory properties of choline and its dietary forms throughout the lifespan.

The Journal of nutrition·2026
Same journal

Oat-rich low-gluten diet modulates plasma short-chain fatty acids without significant changes in fecal microbiome or inflammatory markers - a randomized clinical trial in people with cardiometabolic risk.

The Journal of nutrition·2026
Same journal

Diet and Cognitive Function in Aging: An Individual Participant Data Meta-Analysis from Eight Cohorts in Europe and the United States.

The Journal of nutrition·2026
See all related articles

Beta-hydroxy-beta-methylbutyrate (HMB) supplementation is safe for exercise enhancement. Studies show HMB improves mood and cardiovascular health markers, with no adverse effects on tissue function.

Area of Science:

  • Exercise Science
  • Nutritional Biochemistry
  • Human Physiology

Background:

  • Beta-hydroxy-beta-methylbutyrate (HMB) is a leucine metabolite known to enhance exercise effects on muscle growth and strength.
  • While animal and human studies suggest HMB safety, definitive quantitative human safety data are lacking.

Purpose of the Study:

  • To summarize safety data from nine human studies involving daily HMB supplementation.
  • To assess the impact of HMB on organ function, emotional perception, and overall health.

Main Methods:

  • Nine human studies (3-8 weeks duration) with participants of varying ages and exercise statuses were analyzed.
  • Safety was evaluated through blood chemistry, hematology, emotional profile testing (Circumplex), and a health questionnaire.
  • HMB dosage was consistently 3 grams per day.

Related Experiment Videos

Main Results:

  • HMB did not adversely affect any surrogate markers of tissue health or function.
  • HMB supplementation led to significant improvements in negative mood indicators (Unactivated Unpleasant Affect).
  • Compared to placebo, HMB decreased total cholesterol, LDL cholesterol, and systolic blood pressure, suggesting cardiovascular benefits.

Conclusions:

  • Objective data from nine experiments indicate HMB is safe as an ergogenic aid for exercise.
  • HMB supplementation appears to enhance objective health measures and subjective well-being.
  • Potential cardiovascular benefits, including reduced risk of heart attack and stroke, warrant further investigation.