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Varicella zoster viral disease
1Department of Ophthalmology, Mayo Clinic Jacksonville, FL 32224, USA.
Mayo Clinic Proceedings
|August 5, 2000
Summary
Herpes zoster, a viral disease, causes significant illness, particularly in older adults. Advances in understanding varicella zoster virus biology and new treatments offer hope for managing acute episodes and preventing future outbreaks.
Area of Science:
- Virology
- Epidemiology
- Immunology
Background:
- Herpes zoster (shingles) is a significant cause of morbidity, especially in elderly populations.
- Ophthalmic zoster presents a particular challenge due to its high incidence and severity.
- Research into varicella zoster virus (VZV) has improved understanding of disease mechanisms and treatment.
Purpose of the Study:
- To review the epidemiology, biology, and latency of herpes zoster.
- To discuss the pathophysiology of herpes zoster and its complications.
- To outline current and emerging treatment strategies for herpes zoster and postherpetic neuralgia.
Main Methods:
- Literature review of herpes zoster epidemiology, VZV biology, and pathophysiology.
- Analysis of current therapeutic interventions, including antivirals and corticosteroids.
- Evaluation of the impact and potential of the varicella vaccine.
Main Results:
- Herpes zoster incidence may be slightly higher in females.
- Ophthalmic zoster is a common and severe manifestation.
- Effective treatments for acute herpes zoster and postherpetic neuralgia are available.
Conclusions:
- Continued research enhances the management of herpes zoster.
- The varicella vaccine shows promise in reducing the future burden of herpes zoster.
- Comprehensive understanding of VZV is crucial for effective patient care.