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Synthetic oligonucleotide combinatorial libraries and their applications
W T Markiewicz1, A Astriab, P Godzina
1Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Farmaco (Societa Chimica Italiana : 1989)
|August 5, 2000
Abstract:
The application of synthetic oligonucleotide combinatorial libraries is described in the studies of triplex DNA. A new method of selection of dispersed (beaded) oligonucleotide combinatorial libraries based on the use of streptavidin magnetic beads is presented. A combinatorial chemistry approach is also proposed for studies of polyaminooligonucleotides.