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[Diffuse retinal pigmented epitheliopathy associated with systemic corticosteroid therapy].

C W Spraul1, M J Jakobczyk-Zmija, G K Lang

  • 1Universitäts-Augenklinik Ulm. christoph.spraul@medizin.uni-ulm.de

Klinische Monatsblatter Fur Augenheilkunde
|August 5, 2000
PubMed
Summary

Systemic corticosteroids can cause ocular side effects, including retinal pigment epitheliopathy. Discontinuing steroid treatment improved vision and resolved retinal detachment in one patient.

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Area of Science:

  • Ophthalmology
  • Endocrinology

Background:

  • Corticosteroids, widely used for various conditions, are known to cause ocular side effects.
  • Common side effects include cataracts and elevated intraocular pressure.
  • Alterations in the retinal pigment epithelium (RPE) are also a potential risk.

Observation:

  • A 64-year-old male patient presented with a 6-week history of progressively worsening visual acuity.
  • Ophthalmologic examination revealed severe, diffuse retinal pigment epitheliopathy and serous neurosensory retinal detachment.
  • The patient was undergoing treatment with systemic methylprednisolone for chronic glomerulonephritis.

Findings:

  • Following cessation of systemic corticosteroid therapy, the patient experienced significant improvement in visual acuity.
  • The serous retinal detachment observed in the patient resolved after discontinuing the medication.

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Implications:

  • Regular ophthalmologic examinations, including retinal biomicroscopy, are crucial for patients on systemic corticosteroid therapy.
  • Early detection of pigment epithelial changes necessitates consideration of reducing or discontinuing steroid treatment when clinically feasible.