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Updated: Aug 13, 2026
09:08
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Primary cutaneous T-cell lymphoma: review and current concepts
R S Siegel1, T Pandolfino, J Guitart
1Departments of Hematology/Oncology and Dermatology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL, USA. r_siegel@northwestern.edu
Summary
Primary cutaneous T-cell lymphomas (CTCLs), including mycosis fungoides (MF) and Sézary syndrome (SS), are skin-localized lymphomas. While often indolent, transformation to aggressive forms carries a poor prognosis, necessitating ongoing research into novel therapies.
Area of Science:
- Dermatology
- Oncology
- Hematology
Background:
- Primary cutaneous T-cell lymphomas (CTCLs) are a diverse group of skin-localized malignant lymphomas.
- Advances in molecular techniques aid diagnosis and subclassification, yet classification, prognosis, and management remain challenging.
- Mycosis fungoides (MF) and Sézary syndrome (SS) are the most prevalent CTCL subtypes.
Purpose of the Study:
- To review the diagnosis, prognosis, and treatment of CTCL.
- To emphasize MF and SS within the CTCL spectrum.
- To discuss the differential diagnosis of CTCL.
Main Methods:
- Comprehensive review of the medical literature on CTCL.
- Inclusion of diseases within the differential diagnosis of CTCL.
Main Results:
- MF and SS are the most common CTCLs with unknown etiology.
- Diagnosis can be delayed, with patients experiencing prolonged skin abnormalities.
- T1 stage MF/SS patients have a normal life expectancy; transformation to large-cell lymphoma (8-23%) portends a poor prognosis (2-19 months survival).
Conclusions:
- MF/SS is typically indolent, but transformation significantly impacts prognosis.
- Current treatments for MF/SS are primarily palliative.
- Investigational therapies and recently approved agents offer new hope for refractory cases.
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