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[Infantile spasms: experience in 13 cases].

L F Fonseca1, A L Oliveira

  • 1Serviço de Neurologia Infantil, Centro Geral de Pediatria, Fundação Hospitalar do Estado de Minas Gerais, Belo Horizonte, Brasil.

Arquivos De Neuro-Psiquiatria
|August 2, 2000
PubMed
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Infantile spasms, a serious childhood condition, showed excellent initial response to ACTH treatment. However, a high recurrence rate necessitates further therapeutic strategies and highlights the risk of neurodevelopmental delays.

Area of Science:

  • Pediatric Neurology
  • Epileptology

Context:

  • Infantile spasms represent a severe childhood epilepsy with uncertain outcomes.
  • This study reviews a 1997 cohort from Belo Horizonte, Brazil.

Purpose:

  • To evaluate the efficacy and safety of ACTH in treating infantile spasms.
  • To explore treatment outcomes, recurrence rates, and neurodevelopmental impact.

Summary:

  • Twelve symptomatic and one cryptogenic infantile spasm case were treated with 6-week ACTH therapy and oral antiepileptics.
  • ACTH demonstrated excellent initial results with manageable side effects.
  • A 55% recurrence rate was observed, with vigabatrin effective in 4 of 5 cases as a second-line treatment.
  • All cases exhibited neuropsychomotor development retardation.

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Impact:

  • ACTH is effective for initial infantile spasm control.
  • High recurrence rates underscore the need for long-term management strategies.
  • Neuropsychomotor retardation is a significant complication requiring ongoing assessment.