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[The predominant expression of Th2 type cytokines in human tumor cells]
1Shandong Cancer Biotherapy Center, Shandong Academy of Medical Sciences, Jinan.
Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology]
|August 2, 2000
Abstract
Objective:
To observe the expression of Th1 versus Th2 type cytokines in human tumor cells.
Methods:
The gene expression of Th1/Th2 cytokines in human tumor cells was detected by RT-PCR and RNA dot hybridization using IL-2 and IFN gamma as Th1 type cytokine genes, IL-4, IL-10 and IL-13 as Th2 type cytokine genes.
Results:
There were predominant expressions of Th2 type cytokines in 20 different human tumor cell lines including 11 solid tumor and 9 hematogenous tumor cells.
Conclusion:
Predominant expression of Th2 type cytokines by tumor cells may be related to the evasion of tumor cells from immune surveillance.