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[Telomerase activity in human gastric and colorectal cancer]
1Department of Health Toxicology, Sun Yat-sen University of Medical Sciences, Guangzhou.
Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology]
|August 2, 2000
Abstract
Objective:
To study telomerase activity in patients with gastric and colorectal cancer.
Methods:
Telomerase activity in tumor samples, including 9 colonic, 20 rectal and 11 gastric carcinomas, was examined by telomeric repeat amplification protocol(TRAP) assay. Thirty-nine samples from tumor-adjacent tissues were also assayed.
Results:
Ninety per cent(36 out of 40 tumor samples) exhibited telomerase activity regardless of tumor stage or differentiation. However, telomerase activity in the tumor-adjacent tissues could be detected only in 1 of 39 specimens.
Conclusion:
Telomerase may be a good diagnostic biomarker for tumor detection.