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[CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility]
Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology]
|August 2, 2000
Abstract
Objective:
To evaluate the relationship between CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility among Cantonese in China.
Methods:
In a case-control study, PCR was used to identify CYP2D6 and GSTM1 genotypes and restriction enzyme BstNI was used to identify a specific point mutation of CYP2D6.
Results:
Between lung cancer patient group and normal control group CYP2D6 genetic polymorphism did not show frequency distribution differences but that of GSTM1 did (58.7% n = 46, 35.7%, n = 70, P < 0.05) OR = 2.56(1.11-2.44).
Conclusion:
There is no association between CYP2D6 G-A mutation and lung cancer susceptibility, while individuals with GSTM1 -/- genotype are susceptible to lung cancer.