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Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
Published on: January 25, 2015
[Early postoperative intraperitoneal perfusion chemotherapy for advanced colorectal cancer]
1Department of General Surgery, Southwest Hospital, Third Military Medical University, Chongqing.
Objective:
To study the effect of early postoperative intraperitoneal perfusion chemotherapy (IPPC) on the prevention of peritoneal recurrence and liver metastasis in patients with advanced colorectal cancer.
Methods:
From 1990 through 1997, 102 patients with advanced colorectal cancer were admitted. The tumor invaded the intestinal serosa with elevated CEA in the peritoneal fluid. Fifty-four of the 102 patients, beginning from the operation day, were given IPPC, once per day for 6 days, with warm(43-45 degrees C) sterile double distilled water containing 1 g 5-Fu and 10 mg MMC. The other 48 patients, as control, received 1 g 5-Fu and 8 mg MMC by i.v. infusion, once per day for 6 days. In addition, oral tegafur was given to all patients with a total dose of 40 g.
Results:
In patients treated with IPPC, peritoneal recurrence developed in 2 patients, liver metastasis in 2 patients whereas 12 cases had peritoneal recurrence and 6 had liver metastasis in patients treated by i.v. infusion. No complication developed in any of the treated patients.
Conclusion:
IPPC is effective in preventing tumor recurrence in the peritoneal cavity and metastasis to the liver in patients with advanced colorectal cancer. The treatment procedure is simple and safe.
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