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[Study on the correlation between CT features and expression of p53 protein and PCNA in peripheral lung cancer]
1Department of Interventional Radiology, Tangdu Hospital, Fourth Military Medical University, Xian.
Objective:
To investigate the correlation between CT features and expression of p53 protein and PCNA in peripheral lung cancer.
Methods:
The expression of p53 protein and PCNA was examined by means of SP immunohistochemical technique in 32 cases of peripheral lung cancer proved by pathology; the relationship between the results and preoperative CT features was analyzed retrospectively.
Results:
The expression of p53 protein and PCNA was correlated with tumor size, deep lobulation, frank cavitation, pleural indentation and mediastinal lymph node metastasis, but not with spiculation.
Conclusion:
The CT features of peripheral lung cancer with diameter more than 3 cm, deep lobulation, frank cavitation, pleural indentation or mediastinal lymph node metastasis indicate higher degree of malignancy and proliferative activity of tumor cells.