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[Infection of GBV-C virus among hepatitis and HCC patients]
1Telecommunications General Hospital, 8th Medical Clinic College, Beijing Medical University.
Insights
Hepatitis G virus (HGV) is prevalent and frequently co-infects with Hepatitis B virus (HBV) and Hepatitis C virus (HCV). However, HGV shows minimal association with hepatocellular carcinoma (HCC).
Area of Science:
- Hepatology
- Virology
- Oncology
Context:
- Hepatitis B virus (HBV), Hepatitis C virus (HCV), and Hepatitis G virus (HGV) are significant global health concerns.
- Hepatocellular carcinoma (HCC) is a major complication of chronic viral hepatitis.
Purpose:
- To investigate the prevalence and co-infection rates of Hepatitis G virus (HGV) in patients with HBV, HCV, non-A-E hepatitis, and HCC.
- To determine the association between HGV infection and hepatocellular carcinoma (HCC).
Summary:
- Serum samples from hepatitis patients and HCC patients were analyzed for HGV RNA using RT-PCR.
- HGV infection rates were 9% in HBV patients, 10% in HCV patients, 17% in non-A-E hepatitis patients, and 0% in HCC patients.
- HGV demonstrates a high co-infection rate with HBV and HCV but appears to have little direct association with HCC.
Impact:
- This study highlights HGV as a pervasive virus with significant co-infection potential with HBV and HCV.
- Findings suggest HGV is not a primary driver of hepatocellular carcinoma (HCC).
- Understanding HGV epidemiology is crucial for managing viral hepatitis and its complications.
Abstract:
To study the infection status of GBV-C virus among HBV, HCV, nonA-E and HCC patients, serum of clinical hepatitis patients and HCC patients before operation, and the composition in/beside HCC were collected to examine HGV RNA of the samples, using HGV RT-PCR method. Results showed that among the clinical patients with HBV, HCV, nonA-E and HCC, HGV infection rates were 9% (12/130), 10% (3/30), 17% (4/24), 0% (0/24) respectively, suggesting that HGV is a hepatitis virus with pervasive existence and has high superimposition infection rate with HBV and HCV but with little connection with HCC.