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Impaired coronary microvascular function in diabetics.

G Tsujimoto1

  • 1Department of Internal Medicine, Kobe Rosai Hospital, Japan.

Annals of Nuclear Medicine
|August 2, 2000
PubMed
Summary

Diabetics show impaired coronary microvascular function, evidenced by significantly lower myocardial uptake increase (deltaMTU) compared to controls. This non-invasive method effectively evaluates microvascular function in diabetes.

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Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Diabetology

Background:

  • Coronary microvascular dysfunction is a known complication of diabetes mellitus.
  • Assessing microvascular function non-invasively is crucial for diabetic patient management.

Purpose of the Study:

  • To evaluate impaired coronary microvascular function in patients with non-insulin dependent diabetes mellitus.
  • To assess the utility of myocardial uptake increase (% deltaMTU) as a non-invasive marker.

Main Methods:

  • Utilized technetium-99m tetrofosmin myocardial perfusion imaging.
  • Employed a 4-hour exercise and rest protocol with specific radiotracer doses.
  • Calculated global and regional % uptake increase (deltaMTU) in 24 diabetic patients and 22 controls.

Main Results:

  • Global deltaMTU was significantly lower in diabetics (14.4%) versus controls (21.7%), p < 0.01.
  • Regional deltaMTU was also significantly lower in all four left ventricular regions in diabetics compared to controls (p < 0.01).
  • No significant differences in deltaMTU were observed between the four left ventricular regions within each group.

Conclusions:

  • Myocardial uptake increase (deltaMTU) is significantly impaired in patients with non-insulin dependent diabetes mellitus.
  • deltaMTU serves as a valuable non-invasive tool for evaluating coronary microvascular function in diabetics.
  • Findings highlight the subclinical microvascular impact of diabetes on the heart.

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