Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intrauterine inflammation at term: a histopathologic study.

L Keski-Nisula1, M L Aalto, M L Katila

  • 1Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland.

Human Pathology
|August 3, 2000
PubMed
Summary

Subclinical inflammation in uterine and gestational tissues occurs in nearly 20% of women at term gestation. This inflammation, particularly in the decidua, is linked to cervical dilation and meconium-stained amniotic fluid.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Third-trimester polyunsaturated fatty acid supplementation and increased blood loss at vaginal delivery: A prospective birth cohort study.

European journal of obstetrics, gynecology, and reproductive biology·2026
Same author

Altered activities of CYP1A1 and CYP19A1 enzymes in women using SSRI medication during pregnancy.

Placenta·2022
Same author

Fetal lactate levels align with the stage of labour.

European journal of obstetrics, gynecology, and reproductive biology·2021
Same author

Farm Environment During Pregnancy and Childhood and Polysensitization at the Age of 31: Prospective Birth Cohort Study in Finland.

Journal of investigational allergology & clinical immunology·2019
Same author

Quantity and diversity of environmental microbial exposure and development of asthma: a birth cohort study.

Allergy·2014
Same author

Umbilical cord length in singleton gestations: a Finnish population-based retrospective register study.

Placenta·2014

Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Pathology

Background:

  • Subclinical inflammation of uterine and gestational tissues can impact pregnancy outcomes.
  • Histopathological examination is crucial for identifying inflammatory lesions.
  • Understanding inflammation's correlation with clinical variables is essential for clinical management.

Purpose of the Study:

  • To determine the prevalence of histologically defined inflammation in uterine and gestational tissues.
  • To evaluate the association between inflammation and clinical variables in term gestation.
  • To assess the correlation of inflammation with maternal and neonatal clinical outcomes.

Main Methods:

  • Analysis of 216 clinically noninfected, term parturients undergoing cesarean section with intact membranes.

Related Experiment Videos

  • Histopathological examination of 981 samples: chorion, umbilical cord, placenta, myometrium, and decidua.
  • Microbiological cultures, Gram stain for leukocytes, and leukocyte esterase activity (LEA) of amniotic fluid (AF) were performed.

    • Main Results:

    • Leukocytic infiltrations were found in 19% of examined tissue samples.
    • Low-grade decidual inflammation was observed in 29% of cases after labor onset.
    • Cervical dilation (OR 4.7) and meconium-stained AF (OR 5.3) were significantly associated with decidual inflammation, independent of microbial or leukocyte markers.

    Conclusions:

    • Subclinical inflammation of uterine and gestational tissues is present in a significant proportion of term pregnancies.
    • Decidual inflammation is associated with clinical indicators like cervical dilation and meconium-stained AF.
    • These findings highlight the importance of histopathological assessment and suggest potential clinical predictors of intra-amniotic inflammation.