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Frequency modulation within electrocardiograms during ventricular fibrillation.

A Patwardhan1, S Moghe, K Wang

  • 1Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506, USA. abhijit@pop.uky.edu

American Journal of Physiology. Heart and Circulatory Physiology
|August 3, 2000
PubMed
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Ventricular fibrillation (VF) shows significant frequency changes over time, which are reduced by amiodarone. Dominant frequencies increase linearly during VF and can vary across different body surface electrocardiograms (ECGs).

Area of Science:

  • Cardiovascular Physiology
  • Electrophysiology
  • Signal Processing

Background:

  • Ventricular fibrillation (VF) is characterized by reentrant activation and effective refractory periods, which correlate with dominant frequency (DF) and cycle length.
  • Understanding time-varying DF during VF is crucial for analyzing cardiac electrical activity and developing therapeutic strategies.

Purpose of the Study:

  • To quantify time-varying dominant frequencies in electrocardiograms (ECGs) during ventricular fibrillation (VF) using Wigner transforms.
  • To investigate the effect of amiodarone on dominant frequencies and their variations during VF.
  • To analyze the temporal and spatial characteristics of dominant frequencies during VF.

Main Methods:

  • Wigner transform analysis was applied to orthogonal ECGs recorded from dogs during VF.

Related Experiment Videos

  • Dominant frequencies were estimated during 10-second and 30-second VF trials.
  • Amiodarone's effect was assessed by comparing dominant frequencies before and after administration.

    • Main Results:

    • Significant frequency modulation (+/-15%) was observed during VF, which was reduced by amiodarone.
    • Dominant frequencies increased linearly (0.022 Hz/s) during 30-second VF episodes.
    • Spatial variations in dominant frequencies were noted across different body surface ECG leads during VF.

    Conclusions:

    • ECG frequencies during VF exhibit considerable and continuous variation, with amiodarone decreasing this variability.
    • Mean dominant frequencies increase linearly within the first 30 seconds of VF.
    • Spatial dominant frequencies can be similar or markedly different at any given time during VF.