Related Experiment Video

Updated: Aug 16, 2026

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
14:19

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

Echocardiographic determinants of left ventricular ejection fraction after acute myocardial infarction

B M McClements1, A E Weyman, J B Newell

  • 1Cardiac Ultrasound Laboratory, Cardiology Division, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston 02114, USA.

American Heart Journal
|August 5, 2000
PubMed

Insights

Left ventricular ejection fraction after myocardial infarction is influenced by more than just infarct size. Anterior infarcts with extensive apical involvement result in lower ejection fraction, suggesting unique apex characteristics.

Area of Science:

  • Cardiology
  • Cardiac Imaging
  • Myocardial Infarction Research

Background:

  • Left ventricular ejection fraction (LVEF) is a key prognostic indicator post-myocardial infarction (MI).
  • While infarct size impacts LVEF, the influence of regional dysfunction characteristics remains less understood.

Purpose of the Study:

  • To investigate factors beyond infarct size that affect global LVEF following acute myocardial infarction.
  • To determine if the site and severity of regional wall motion abnormalities influence post-MI LVEF.

Main Methods:

  • Echocardiography was used to assess 69 patients one week after Q-wave MI.
  • Quantified abnormal wall motion (AWM) size (%AWM), wall motion score, and derived a severity index.
  • Classified MI site as anterior or inferior; LVEF measured by Simpson's method.

Main Results:

  • Anterior MIs showed significantly lower LVEF compared to inferior MIs (44.8% vs 53%, P=.001).
  • Anterior MIs had greater %AWM (32.1% vs 22.4%, P=.01) and higher wall motion scores (9.8 vs 6.4, P=.01).
  • Multiple regression identified %AWM, apical involvement extent, and MI site as independent LVEF determinants.

Conclusions:

  • Extensive apical involvement and anterior MI site are associated with lower LVEF, even for similar infarct sizes.
  • These site-dependent differences in LVEF may stem from specific regional myocardial characteristics, particularly in the apex.
Abstract

More Related Videos

Histological Quantification of Chronic Myocardial Infarct in Rats09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

Published on: December 11, 2016

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs08:19

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

Related Concept Videos

Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...